Purpose: We aimed to investigate the electroclinical characteristics of patients having persistent seizures with fever after 5 years of age, which has not been elucidated well.
Methods: We identified 101 patients over 5 years (M : F=64 : 37, range: 5.0-11.0), visited our hospital for febrile seizure. Their medical records for clinical features and EEG findings at last seizure were retrospectively reviewed.
Results: The mean onset age of seizure of total patients was 3.0 years (range: 0.3-8.3). The complex features were noted in 15.8%. Family history were in 53.3%. Neurologic abnormalities were in 10.9%. Abnormal EEGs were in 36.7% (generalized spike or polyspike-waves: 10, focal epileptic discharges: 16, others: 3). When we compare the patients of 5.0-5.9 years (Group A, n=48) to the patients after 6 years (Group B, n=53), complex features (20.8% vs 37.8%, p=0.063) and AED treatments (6.3% vs 18.9%, p=0.059) were more common in Group B. Among group B, patients after 8 years were more apt to be treated by AED than youngers (6.1% vs 40.0%, p=0.002). When we compare the patients starting their first seizure before 5.0 years (Group C, n=78) to the patients after 5.0 years (Group D, n=23), Group C had more frequent seizures (6.6 vs 2.3, p= < 0.0001) and family history (58.3% vs 25.0%, p=0.039). Group D had more common abnormal neurologic findings (7.7% vs 21.7%, p=0.057).
Conclusion: Febrile seizures in older age group are more associ-ated with complex features, EEG abnormalities and AED treatments. The patients with seizure onset before 5.0 years had more seizure frequency and family histories.
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